Bioavailability Enhancement

Our proprietary Biorise® and Diffucaps® technologies can be applied to enable formulation of insoluble drugs and to improve the rate and extent of absorption of drugs from oral dosage forms.

Drug insolubility poses significant challenges during drug development owing to its impact on the extent and rate of drug absorption into the body. It can prevent the absorption of therapeutic levels of drug, delay a drug's onset of action and decrease its therapeutic benefit. These problems can result in patients being given higher and more frequent drug doses, which can result in increased therapy costs, greater likelihood of side effects and complicated dosing regimens. 


Our bioenhancement technologies can improve the bioavailability of insoluble drugs, thus enabling the development of oral dosage forms. There are also clinical benefits that flow from these technologies, including: accelerated onset of action, lower dosage levels, decreased side effects and enhanced product performance. Our bioavailability enhancement technologies are also able to provide unique marketing advantages including extended patent life, reduced development timelines, cost savings, more convenient dosing and, as a result, increased market share. Additionally, our bioavailability enhancement technologies can also provide the key to enabling the development and commercialization of those NCEs that would have otherwise been shelved due to their poor solubility and bioavailability.

Eurand's Bioavailability Enhancement Technology Platform Offers:
 

  • Novel oral dosage forms of problem compounds 
  • Improved clinical profiles and patient compliance
  • Products with a more rapid onset of action
  • Improved dose proportionality
  • Minimized food effect and/or gastric irritation
  • Reduced intra- and inter-subject variability
  • Significant reduction in dose while maintaining therapeutic efficacy
  • Improved safety profiles
  • Better product performance and improved market share
  • Novel oral dosage forms 
  • Extended patent life

For more information on our technology, please visit the Biorise and Diffucaps sections of our website or contact us at partners@eurand.com